
MSKSEMI
A strong pin-to-pin candidate in the same DFN-1006 package with matching key electrical specifications.
Find the best replacements for the ESD5451N-MS TVS diode. This guide reviews pin-compatible and functional alternatives, highlighting key differences in package, capacitance, and electrical ratings.
PESD05NFA-MS is a near-identical electrical match.
All suggested alternatives use the DFN-1006 package or a close variant.
Target and best alternative are from the same niche manufacturer.
Direct replacement for ESD5451N-MS should use only Datasheet verified or Strong match candidates; many approved options still require engineering review.
PESD05NFA-MS is the most direct replacement path, requiring minimal re-qualification.
The main risk is ensuring subtle parametric differences, like dynamic resistance or clamping voltage, do not impact circuit protection.

MSKSEMI
A strong pin-to-pin candidate in the same DFN-1006 package with matching key electrical specifications.
| Feature / factor | ESD5451N-MS | PESD05NFA-MS | PESD5V0C1USF315 | ESD9X5VU-MS | Compatibility / risk |
|---|---|---|---|---|---|
| Package | DFN-1006 | DFN-1006 | DFN1006BD-2 | DFN-1006 | DFN-1006 / DFN1006BD-2 — Matches target package.; PESD5V0C1USF315: DFN-1006 variant, likely compatible.; ESD9X5VU-MS: Matches target package. |
| Voltage | 5.0 V | 5.0 V | 5V | 5.0 V | 5.0 V / 5V — Reverse standoff voltage matches.; PESD5V0C1USF315: Standoff voltage matches.; ESD9X5VU-MS: Standoff voltage matches. |
| Capacitance | 15 pF | 15 pF | 0.4 pF | 0.9 pF | 15 pF / 0.4 pF / 0.9 pF — Junction capacitance matches.; PESD5V0C1USF315: Significantly lower capacitance.; ESD9X5VU-MS: Significantly lower capacitance. |
| Power | 60 W | 60 W | - | Not specified | 60 W / Not specified — Peak pulse power matches.; ESD9X5VU-MS: Peak pulse power rating is missing. |
| Esd Rating | ±30 kV | ±30 kV | - | - | ±30 kV — ESD protection level matches. |
Verified drop-in options for ESD5451N-MS are limited in the current batch. Review candidates marked Strong match or Datasheet verified, and validate package, pinout, and electrical limits before committing a BOM change.