
Murata Electronics
A parametric alternative in the same 0603 package with a higher voltage rating but a different dielectric (X5R vs X6S).
Finding a substitute for the Murata GRT188C80J226ME13D, a 22uF 6.3V 0603 MLCC, requires careful attention to its X6S dielectric and AEC-Q200 qualification. While many parts have similar capacitance and voltage, matching the temperature performance and package size simultaneously is the main challenge.
Dielectric mismatch (X5R vs X6S) affects temperature performance and DC bias characteristics.
Some electrically suitable alternatives are in a different package (0805), requiring board redesign.
Some alternatives are not AEC-Q200 qualified, making them unsuitable for automotive applications.
There are no direct, drop-in replacements without caveats. Candidates with the same 0603 package have a different X5R dielectric, which has a lower maximum operating temperature than the target's X6S.
For new designs, GRT21BC81A226ME13L is electrically superior but requires a larger 0805 footprint. For existing 0603 layouts, GRT188R61A226ME13D is a close option, but its X5R dielectric must be validated against the application's temperature profile.
The primary risk is the dielectric mismatch. Replacing an X6S capacitor with an X5R part can lead to excessive capacitance loss or failure if the operating temperature exceeds 85°C.

Murata Electronics
A parametric alternative in the same 0603 package with a higher voltage rating but a different dielectric (X5R vs X6S).
| Feature / factor | GRT188C80J226ME13D | GRT188R61A226ME13D | GRT21BC81A226ME13L | GRM187R61A226ME15D | Compatibility / risk |
|---|---|---|---|---|---|
| Package | 0603 (1608 metric) | 0603 (1608 metric) | 0805 (2012 metric) | 0603 (1608 metric) | 0603 (1608 metric) / 0805 (2012 metric) / 0603 (1608 Metric) — Package size matches.; GRT21BC81A226ME13L: Larger package requires PCB redesign.; GRM187R61A226ME15D: Package size matches.; ZRB18AR61A226ME01L: Package size matches, but has special interposer termination. |
| Dielectric | X6S | X5R | X6S | X5R | X5R / X6S — Weaker temperature performance. Max temp 85°C vs 105°C.; GRT21BC81A226ME13L: Dielectric characteristics match.; GRM187R61A226ME15D: Weaker temperature performance. Max temp 85°C vs 105°C.; ZRB18AR61A226ME01L: Weaker temperature performance. Max temp 85°C vs 105°C. |
| Voltage | 6.3V | 10V | 10V | 10V | 10V — Higher voltage rating provides more margin.; GRT21BC81A226ME13L: Higher voltage rating provides more margin.; GRM187R61A226ME15D: Higher voltage rating provides more margin.; ZRB18AR61A226ME01L: Higher voltage rating provides more margin. |
| Application | AEC-Q200 | AEC-Q200 | AEC-Q200 | General Purpose | AEC-Q200 / General Purpose — Both are automotive grade.; GRT21BC81A226ME13L: Both are automotive grade.; GRM187R61A226ME15D: Candidate is general purpose (GRM series), target is automotive (GRT series).; ZRB18AR61A226ME01L: Not AEC-Q200 qualified. |
There is no single 'best' alternative. For electrical performance, GRT21BC81A226ME13L is strong but has a larger 0805 package. For the same 0603 package, GRT188R61A226ME13D is a candidate, but you must verify if its X5R dielectric is acceptable for your temperature requirements.