
Texas Instruments
A low-speed alternative with matching package and temperature, but only 500kbps data rate.
SN65HVD78DR is a high-speed 50 Mbps, 3.3V RS-485 transceiver in a standard SOIC-8 package. Finding a direct replacement is challenging, as most alternatives with a similar package operate at significantly lower data rates.
Data rate is 50-100x slower. This is a functional failure for high-speed systems.
All considered alternatives use the same SOIC-8 package, but pinout must be verified.
Changing communication speed may require adjustments to timing, protocols, or firmware settings.
No, a direct 1-to-1 replacement for SN65HVD78DR that matches its 50 Mbps speed was not identified. All compatible package options are significant performance downgrades.
Evaluate if the application can operate at a lower data rate (e.g., <=1 Mbps). If not, a board redesign with a different high-speed transceiver may be necessary.
The main risk is a critical data rate mismatch. Using a substitute will drastically reduce communication speed from 50 Mbps to 1 Mbps or less.

Texas Instruments
A low-speed alternative with matching package and temperature, but only 500kbps data rate.
| Feature / factor | SN65HVD78DR | THVD1410DR | THVD2410DR | SN65HVD12DR | Compatibility / risk |
|---|---|---|---|---|---|
| Package | SOIC-8 | SOIC-8 | SOIC-8 | SOIC-8 | SOIC-8 — Form factor matches.; THVD2410DR: Form factor matches.; SN65HVD12DR: Form factor matches. |
| Voltage | 3.0V - 3.6V | 3V - 5.5V | 3V - 5.5V | 3.3V | 3V - 5.5V / 3.3V — Wider supply voltage range is compatible.; THVD2410DR: Wider supply voltage range is compatible.; SN65HVD12DR: Supply voltage is compatible. |
| Data Rate | 50 Mbps | 500 kbps | 500 kbps | 1 Mbps | 500 kbps / 1 Mbps — Candidate is 100x slower, a major performance downgrade.; THVD2410DR: Candidate is 100x slower, a major performance downgrade.; SN65HVD12DR: Candidate is 50x slower, suitable only for low-speed applications. |
| Temperature | -40°C to 125°C | -40°C to 125°C | -40°C to 125°C | -40°C to 85°C | -40°C to 125°C / -40°C to 85°C — Operating temperature range matches.; THVD2410DR: Operating temperature range matches.; SN65HVD12DR: Candidate has a narrower operating temperature range. |
No direct, high-speed (50 Mbps) replacements were found. If your application can tolerate a lower speed, parts like SN65HVD12DR (1 Mbps) or THVD1410DR (500 kbps) are potential options in the same package and voltage, but require careful review of performance needs.